E-Maculation

I've tried several times to run the aforementioned emulator at the aforementioned resolution. Why does it crash? any help is appreciated.

My Setup (if that helps)
HP Compaq dc7800P SFF (Core2Duo E6750 @ 2.66 GHz)
250 GB SSD (WD Blue)
8 Gigabytes (4x2GB DDR2, 6400)
NVIDIA GeForce 1030 GT 2 GB
Vizio e43u-D2 4k display

Does it also happen with SheepShaver?
I'm not new to Mac emulation, but I'm new to the forum here at Emaculation.
Thank you.

Can you run BII in windowed mode at a lower resolution?

I've had issues with specific multiples of WxH in BII in the past, with BII slowing to a crawl or crashing as you describe. Try starting out in windowed mode at 1024x768 and work your way up to see where the crashes begin.